The action kicks off on Friday night when the two university sides, Bidvest Wits and AmaTuks, clash in Johannesburg.
AmaKhosi play their third and final home game in the Mother City this season when they take on Matsatsanta on Saturday night.
Baxter spent three years with Chiefs, leaving the club at the end of last season after helping them to win the Absa Premiership title.
The Englishman is now in charge at SuperSport after having replaced Gordon Igesund mid-season. Last week’s 2-0 victory over Tuks was his first win since taking charge of the Tshwane side who are in ninth place on the table.
The Soweto giants meanwhile are lying fourth, 10 points behind log leaders Mamelodi Sundowns.
It was always going to be a difficult job for the new man, Steve Komphela, having to better or equal Baxter’s achievements. The former Bafana Bafana coach says however he respects what Komphela has done at Chiefs to date.
“It’s a difficult job. I am not blowing my own trumpet by saying that we had three good years,” said Baxter.
“The club got some silverware. That’s never an easy job. So Steve comes in and every time they drop a point it’s not good enough. Look at the bigger picture and Steve has manned up for me.”
Chiefs have won their last three league matches, while SuperSport have a win, draw and a loss to show for their efforts.
The first round affair between the two sides ended in a 4-1 victory for Chiefs.
AmaKhosi have won four and lost one of the last five matches between the two sides in league and cup competition.
Bidvest Wits v University of Pretoria Bidvest Stadium (8pm)
Polokwane City v Ajax Cape Town, Old Peter Mokaba Stadium (3.30pm)
Chippa United v Free State Stars, Nelson Mandela Bay Stadium (3.30pm).
Mamelodi Sundowns v Golden Arrows, Lucas Moripe Stadium (6pm)
Kaizer Chiefs v SuperSport United, Cape Town Stadium (8.15pm)
Platinum Stars v Jomo Cosmos, Moruleng Stadium (3.30pm)
Bloem Celtic v Maritzburg Utd, Dr Molemela Stadium (3.30pm)
Black Aces v Orlando Pirates, Mbombela Stadium (3.30pm)
African News Agency
Original source: Chiefs brace for battle with Baxter