Duminy, who hasn’t been in the best of form of late, has made way for another left-hander in Rilee Rossouw in the South African middle-order, after captain AB de Villiers won the toss and elected to bowl first.
The series is locked at 2-2 after four matches, and a capacity crowd at Newlands will hope that the Proteas can clinch their third consecutive victory after being 2-0 down in the series.
England remained unchanged from the side that lost by one wicket in a thrilling encounter at the Wanderers on Friday night, where Chris Morris played the innings of his life smashing 62 off 38 balls to win the match for the Proteas and claim the man-of-the-match award.
TEAMS FOR NEWLANDS
South Africa: Quinton de Kock, Hashim Amla, Faf du Plessis, AB de Villiers (captain), Rilee Rossouw, Farhaan Behardien, David Wiese, Chris Morris, Kagiso Rabada, Kyle Abbott, Imran Tahir.
England: Jason Roy, Alex Hales, Joe Root, Eoin Morgan, Ben Stokes, Jos Buttler, Moeen Ali, Chris Woakes, Adil Rashid, Stuart Broad, Reece Topley.
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@IndyCapeSportJP Duminy has been dropped from the Proteas for the final and series-deciding ODI against England at Newlands.
Original source: Duminy dropped as Proteas bowl first