Eight Premier Division clubs will be in action in the Eastern Cape city where the reserve league action will take place on Saturday and Sunday.
Sundowns will be eager to put some daylight between themselves and the second-placed Lamontville Golden Arrows side.
Chippa United, playing on their home turf, will also be in action against Kaizer Chiefs on Sunday.
The Chilli Boys have not enjoyed a good outing so far - losing eight of their 11 matches so far.
However, they are one of only two sides to have beaten the table topping Sundowns.
All matches will be broadcast live on SuperSport 4 (DSTV channel 204) and SuperSport Select (DSTV channel 210) and on community TV channels on DSTV.
African News Agency
Original source: Sundowns out to extend Diski advantage